CVTree constructs whole-genome based phylogenetic trees without sequence alignment by using a Composition Vector (CV) approach. It was first developed to infer evolutionary relatedness of microbial organisms and then successfully applied to viruses, chloroplasts, and fungi.
It circumvents the ambiguity of choosing the genes for
phylogenetic reconstruction and avoids the necessity of aligning sequences of essentially
different length and gene content. Please read the Online User's Manualfor details.
Reference: Zhao Xu, Bailin Hao, "CVTree update: a newly designed phylogenetic study platform using composition vectors and whole genomes", Nucleic Acids Res. 2009 37(Web Server issue): W174-W178.